home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Retrovirus Envelope Protein Induces Lung Tumours In Mice

 
  April, 19 2005 10:04
your information resource in human molecular genetics
 
     
A sheep retrovirus envelope protein is enough to trigger tumour formation in the lungs of immunodeficient mice, according to a letter in the 14 April 2005 issue of Nature (Vol. 434, No. 7035, pp. 904-907). This is the first example of a retroviral structural protein that induces tumorigenesis.

Jaagsiekte sheep retrovirus, which killed Dolly, the famous cloned sheep, causes a contagious lung cancer in sheep and goats that can lead to a significant loss of livestock. Although it has previously been shown that the viral envelope protein can transform cells in culture, the mechanism for tumour formation remains unknown. Now, Dusty Miller and colleagues report that expression of the retrovirus envelope protein in the lungs of mice causes tumorigenesis. Interaction of this protein with the sheep viral entry receptor, hyaluronidase 2, is not required, although it may facilitate tumour formation in other species.

Interestingly, the virus protein caused lethal disease in immunodeficient mice, but tumour development was almost entirely blocked in immunocompetent mice. The authors suggest that immune responses to the envelope protein may protect against the formation of tumours.

CONTACT

Dusty Miller (Fred Hutchinson Cancer Research Center, Seattle, WA, USA)
E-mail: dmiller@fhcrc.org

(C) Nature press release


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2016 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.