news archive April 2003

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• Young Neurons In Old Brains
  The functional properties of adult-born neurons develop in a different order than that seen in young animals.
  
• Organ Alchemy: Producing Insulin In The Liver
  Introducing pancreatic genes into cells in the adult liver directs those cells to produce insulin and reverses diabetes in a mouse model of the disease.
  
• Lost Genes Lend New Strength To TB Vaccine
  Reinforcing the existing tuberculosis (TB) vaccine with new genes from the microbe that causes the disease makes the vaccine more effective.
  
• Smart Bone Repair
  'Smart' material may eventually be useful for healing injured bone or other tissues in human patients.
  
• Suicidal Gene Therapy Fights Hepatitis C
  Scientists demonstrate that adenoviral gene therapy can lead to significant reductions in levels of hepatitis C virus in mice containing virally infected human liver cells.
  
• Stem Cell Injections Improve Paralysis In Mouse Model Of Multiple Sclerosis
  Researchers hope that, in future, similar therapies will be used to treat human MS and other autoimmune diseases.
  
• Understanding How Blood Is Made
  A key gene involved in the production and growth of blood stem cells, Bmi-1, regulates the activity of normal and cancerous blood stem cells.
  

• Transplanted Organs Bear Perilous Passengers
  Tumor cells hidden in a transplanted organ can cause Kaposi sarcoma (KS) in the organ recipient.
  
• Dysfunctional Gene Dooms Ovarian Tumors
  Small alterations in a gene required for responding to chemotherapy can result in drug-resistant ovarian cancer.
  
• Target And Switch
  Two studies explain how immunoglobulin genes are uniquely identified to switch and why other genes aren't accidentally mangled.
  
• p53 Ways To Kill A Cell
  The phosphatase PAC1 is necessary and sufficient to induce p53-dependent cell death.
  
• Biology's Own 'Department Of Homeland Security'
  Structures of the human enzyme hCE1 suggest how hCE1 is able to bind to a wide range of substrates (drugs and chemical warfare agents).
  
• Cancer Stems From Early Stem Cells
  Mathematical model suggests that some late-life cancers may be due to defects occurring in early development.
  

• NCI Study Estimates More Than 2 Million Women Could Benefit From Tamoxifen
  Tamoxifen chemoprevention for women in the United States
  
• Hydroxyurea Therapy Improves Survival in Most Severely Affected Sickle Cell Patients
  Sickle cell anemia patients who took the drug hydroxyurea over a 9-year period experienced a 40 percent reduction in deaths.
  
• Accident in Animal Lab Raises Questions About a Chemical Used in Some Plastics
  A sudden increase in chromosome abnormalities in a mouse colony has raised questions about the safe level of exposure for bisphenol A.
  

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