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The STREGA initiative: Guidelines for the reporting of genetic association studies

  March, 19 2009 21:58
your information resource in human molecular genetics
There are tens of thousands of published association studies investigating the possible role of candidate genes in several medical conditions. However, there is a large variability in the amount and type of information reported in those papers, which means that the comparison and synthesis of published data in these areas can be sometimes difficult.  

A multi-institutional team has published a recent paper describing the STREGA (STrengthening the REporting of Genetic Association studies) guidelines. These guidelines are aimed to provide a framework that allows a better reporting of data of published papers describing results from genetic association studies. It is composed of 22 items related to different topics of the Introduction (for example, to state clearly if it is a first report or is a replication), Methods (for example, to report the error and call rates of the genotyping platforms used in the study), Results (for example, to indicate numbers of individuals in whom genotyping was attempted/successful) and Discussion sections of the papers.  

Previous examples of similar initiatives from different areas of medical research suggest that the implementation of the guidelines will lead to increased transparency of reporting in the field of genetic association studies, which in turn will help identify potential biases.

What are the main perspectives for STREGA for the near future?    

"In the near future, reactions from people involved in design, conduct, analysis and interpretation of genetic association studies, both formally in the literature (see for example, Vandenbroucke JP. Journal of Clinical Epidemiology 2009 doi: 10.1016/j.jclinepi.2008.12.003) and through the website, and endorsement by journals". Julian Little, PhD    

Contact: Julian Little, PhD, Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada. Email: jlittle@uottawa.ca    


-Little J, Higgins JP, Ioannidis JP, Moher D, Gagnon F, von Elm E, Khoury MJ, Cohen B, Davey-Smith G, Grimshaw J, Scheet P, Gwinn M, Williamson RE, Zou GY, Hutchings K, Johnson CY, Tait V, Wiens M, Golding J, van Duijn C, McLaughlin J, Paterson A, Wells G, Fortier I, Freedman M, Zecevic M, King R, Infante-Rivard C, Stewart A, Birkett N. STrengthening the REporting of Genetic Association Studies (STREGA)- An Extension of the STROBE Statement. PLoS Med. 2009 Feb 3;6(2):e22.


STREGA Reporting Recommendations (in Word format)                

Message posted by: Diego Forero

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