home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Caffeine Protects From UV Damage

  March, 5 2009 20:12
your information resource in human molecular genetics
The mechanism by which caffeine may protect the skin against the damage of UV exposure is revealed in a study published online this in the Journal of Investigative Dermatology. Studies in mice have already shown that caffeine helps to eliminate UV-damaged cells by causing them to commit suicide, but this marks the first study to assess the effect in human cells.

Several studies have reported that in humans, consumption of tea or coffee is associated with lower incidences of nonmelanoma skin cancers. To find out why this might be, Paul Nghiem and colleagues studied the effects of caffeine on cultured human skin cells after exposure to UV. They showed that caffeine interrupts a checkpoint in the cell cycle known as ATR-Chk1, causing the cell to self-destruct. This effect was seen only in cells that were damaged by UV, and therefore more likely to become cancerous, whilst healthy cells were left unchanged.

With over a million new cases in the United States each year, nonmelanoma skin cancer is the most common form of cancer in humans. These results suggest that a topical application of caffeine might one day be developed to minimize or reverse the effects of UV damage in humans.

Author contact

Paul Nghiem (University of Washington, Seattle, WA, USA)
E-mail: pnghiem@u.washington.edu

(C) Journal of Investigative Dermatology press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2021 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.