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Many recent approaches to gene therapy employ non-viral gene delivery with the ultimate aim of improving regenerative medicine and tissue engineering.
Recent data show that the elastic modulus of the matrix directly influences both the cell proliferation and the gene uptake, and additionally promotes DNA release from the complexes. So embedding complexed DNA into a matrix of high elastic modulus might further improve cell proliferation and the longevity and levels of gene expression. The authors, in a News and Commentary article published in Gene Therapy, discuss how matrix-based approaches provide a solid foundation for the application of gene therapies for tissue regeneration and engineering. Author Contact: C. C. Conwell
Division of Drug Delivery and Disposition, University of North Carolina School of Pharmacy, Chapel Hill, NC 27599-7360, USA.
E-mail: cconwell@unc.edu L Huang
Division of Drug Delivery and Disposition, University of North Carolina School of Pharmacy, Chapel Hill, NC 27599-7360, USA.
E-mail: leafh@unc.edu Article available online. (C) Gene Therapy press release. Posted by: Tressie Dalaya
Message posted by: Trevor M. D'Souza
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