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It has never been proven beyond doubt that a mammal has been cloned from a fully mature adult cell, rather than from one of the rare stem cells found in adult bodies. US researchers have now gone some way to establish that cloning from mature adult cells is indeed possible by making cloned mice from B and T lymphocytes, white blood cells active in immune defense. They describe their work in a letter to Nature published online this week.
Konrad Hochedlinger and Rudolf Jaenisch of the Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, used lymphocytes because they undergo genetic shuffling, making them easy to distinguish from other cells in the donor. They reprogrammed these cells to become embryonic stem cells, and then made embryos from this cell line. It has so far proved impossible to make cloned embryos directly from lymphocytes.
Author contacts: Rudolf Jaenisch
Whitehead Institute for Biomedical Research
MIT, Cambridge
MA, USA
Tel: +1 617 258 5186
E-mail: jaenisch@wi.mit.edu Konrad Hochedlinger
Whitehead Institute for Biomedical Research
MIT, Cambridge
MA, USA
Tel: +1 617 258 5205
E-mail: hochedlinger@wi.mit.edu (C) Nature press release.
Message posted by: Trevor M. D'Souza
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