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Gene expression profiling provides a powerful tool for gaining both a snapshot of the genetic state of a cell and a broad perspective on global genetic changes in larger networks. The complex makeup of the central nervous system makes useful application of current profiling methods extremely challenging, if only because of the huge number of different cell types present in the brain; The gene expression of each of these cells can vary dramatically from one to the next. The February issue of Genome Research presents work by Dr. Desmond J. Smith and colleagues at the University of California, Los Angeles, presenting an intriguing method for profiling gene expression in the brain utilizing a technique called "voxelation." Voxelation allows comparison of gene expression from specified cubes of tissues, allowing comparison of identical regions of different brains at the same time, reducing sampling error and providing greater standardization. The method especially allows one to begin to see the minority genetic voices coming from smaller groups of cells.
“High-Throughput Imaging of Brain Gene Expression”
Vanessa M. Brown, Alex Ossadtchi, Arshad H. Khan, Simon R. Cherry, Richard M. Leahy, and Desmond J. Smith
Genome Research
February 1, 2002, 12 (2).
(FREE ACCESS to PAPER)
Message posted by: Frank S. Zollmann
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