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Reproductive ACE

 
  January, 25 2005 10:38
your information resource in human molecular genetics
 
     
A protein that controls blood pressure is also crucial for fertilization, as shown in a report in the February issue of Nature Medicine.

Angiotensin-converting enzyme (ACE) regulates blood pressure indirectly by cutting (and therefore activating) proteins such as angiotensin. In the new study, Gen Kondoh and his colleagues describe a radically new biochemical activity for ACE: it cleaves lipids that attach proteins to membranes, releasing the peptides to act away from the cell. Moreover, sperm from mice that lack ACE have problems attaching to eggs, a deficiency that can be reversed by restoring its lipid-, but not its protein-cleaving activity, show the authors.

These results show that ACE has a crucial role in fertilization, which depends on a hitherto unknown biochemical activity of the enzyme.

Author contact:

Gen Kondoh
Kyoto University, Japan.
Tel: + 81 75 751 4860
E-mail: kondohg@frontier.kyoto-u.ac.jp

Also available online.

(C) Nature Medicine press release.


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