home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Reproductive ACE

  January, 25 2005 10:38
your information resource in human molecular genetics
A protein that controls blood pressure is also crucial for fertilization, as shown in a report in the February issue of Nature Medicine.

Angiotensin-converting enzyme (ACE) regulates blood pressure indirectly by cutting (and therefore activating) proteins such as angiotensin. In the new study, Gen Kondoh and his colleagues describe a radically new biochemical activity for ACE: it cleaves lipids that attach proteins to membranes, releasing the peptides to act away from the cell. Moreover, sperm from mice that lack ACE have problems attaching to eggs, a deficiency that can be reversed by restoring its lipid-, but not its protein-cleaving activity, show the authors.

These results show that ACE has a crucial role in fertilization, which depends on a hitherto unknown biochemical activity of the enzyme.

Author contact:

Gen Kondoh
Kyoto University, Japan.
Tel: + 81 75 751 4860
E-mail: kondohg@frontier.kyoto-u.ac.jp

Also available online.

(C) Nature Medicine press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2018 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.