Sildenafil, better known as Viagra, can prevent and reverse the pathological growth of the heart, according to a report in the February issue of Nature Medicine.
Sustained pressure overload induces abnormal growth of the heart, leading to its failure. Now, David Kass and his colleagues show that sildenafil, a blocker of the enzyme called phosphodiesterase-5A prevents and reverses this growth, improving heart function in mice exposed to chronic cardiac overload.
These results open the possibility that the popular blue tablet may be useful to treat cardiac afflictions of this type in people.
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