home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Passing Inhibitory Small RNA To Your Progeny

 
  January, 20 2003 9:57
your information resource in human molecular genetics
 
     
RNA interference (RNAi) is one of the hottest topics in science these days. The ability of small RNA molecules to inhibit the expression of specific genes has made RNAi an extremely useful tool in modern biology. A paper in the February issue of Nature Structural Biology reports the creation of transgenic mice, in which inherited RNAi lowers the expression of a target gene. The result extends the power of RNAi to genetic studies in live animals.

RNAi generates genome diversity, is a host-defense mechanism and controls gene expression through regulatory feedback mechanisms. It is also a tremendously promising tool in stem cell research and tissue engineering. To make RNAi a viable tool to study the functions of genes in mice, Rosenquist, Hannon and collaborators (State University of New York at Stony Brook and Cold Spring Harbor Laboratory, USA) generated embryonic stem cells containing an RNAi signal targeted to a specific gene. Chimeric animals produced using these cells had offspring that inherited the RNAi signal and showed a lowered expression of the target gene. The creation of germline transgenic mice with an engineered and effective RNAi pathway opens the door to the manipulation of gene activity in living animals.

Author contact:
Thomas A. Rosenquist
Pharmacological Sciences
State University of New York
Stony Brook, NY, USA
Tel: +1 631 444 8054
E-mail: rosenquist@pharm.sunysb.edu


Gregory J. Hannon
Cold Spring Harbor Laboratory
Cold Spring Harbor
NY, USA
Tel: +1 516 367 8889
E-mail: hannon@cshl.edu

(C) Nature Structural Biology press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2016 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.