HUM-MOLGEN archive: HUM-MOLGEN News Alert

__________________________________________________________________________ Advances in Functional Genomics Conference & Exhibition San Francisco, CA - 25-26 April 2006 => http://hum-molgen.org/promotion-FG __________________________________________________________________________ INTERNATIONAL COMMUNICATION FORUM IN HUMAN MOLECULAR GENETICS HUM-MOLGEN News Alert - March 15, 2006 - http://hum-molgen.org Genetic News by T.M. D'Souza, S. Chandler, T. Dalaya, K. Markey, J. Mill, La Merie S.L, R. Nemade, D. Sharma, F.S. Zollmann http://hum-molgen.org/NewsGen - Partners In Crime Scientists have defined the detailed architecture of an enzyme crucial for the replication of two major human viruses. http://hum-molgen.org/NewsGen/03-2006/msg27.html - Protein Teamwork Underlies Skeleton Researchers show how mutations in two different proteins can cause osteopetrosis, a rare congenital human disorder. http://hum-molgen.org/NewsGen/03-2006/msg26.html - It's All In The Expression Changes in the expression level of certain genes may underlie some of the fundamental differences between humans and chimpanzees. http://hum-molgen.org/NewsGen/03-2006/msg25.html - Coral Compound Blocks Viruses A small molecule has been discovered in coral that can be used to block the replication of certain viruses. http://hum-molgen.org/NewsGen/03-2006/msg24.html - A Murine Model for Human Sepiapterin-Reductase Deficiency The Sepiapterin reductase gene (SPR) is essential for homeostasis of tetrahydrobiopterin (BH4) and for the normal functions of BH4-dependent enzymes. http://hum-molgen.org/NewsGen/03-2006/msg22.html - Hemizygosity at the NCF1 Gene in Patients with Williams-Beuren Syndrome Decreases Their Risk of Hypertension The loss of a functional copy of the NCF1 gene protects a proportion of patients with WBS against hypertension. http://hum-molgen.org/NewsGen/03-2006/msg21.html - Spread of an Inactive Form of Caspase-12 in Humans Is Due to Recent Positive Selection The authors suggest that the inactive form of the human caspase-12 gene arose in Africa 100–500 thousand years ago. http://hum-molgen.org/NewsGen/03-2006/msg20.html - The Power to Detect Disease Associations with Mitochondrial DNA Haplogroups Scientists used a simulation-based (Monte Carlo) permutation test to generate power curves for European mtDNA haplogroup studies. http://hum-molgen.org/NewsGen/03-2006/msg19.html - A model for studying cell plasticity in the embryonic microenvironment Transplanted human metastatic melanoma cells resemble neural crest stem cells in the chick embryo. http://hum-molgen.org/NewsGen/03-2006/msg18.html - The irresistible sirene’s chant of needle-free insulins Insulin analogs are conquering the insulin market, inhaled insulins are the next generation, and oral insulins might bypass other delivery technologies http://hum-molgen.org/NewsGen/03-2006/msg17.html - Potential Marker To Identify Sickle Cell Patients at High Risk of Complications Enzyme lactate dehydrogenase (LDH) holds promise in patients with sickle cell disease as a marker for risk of complications, including early death. http://hum-molgen.org/NewsGen/03-2006/msg16.html - Genetic Variations in the Immune System Influence Diseases in Surprising New Ways Variations in the Complement System have a way of influencing diseases such as age-related macular degeneration and cancer. http://hum-molgen.org/NewsGen/03-2006/msg15.html - Natalizumab: Proceed with Caution Natalizumab used to treat multiple sclerosis, Crohn’s disease, and rheumatoid arthritis may or may not be linked to progressive multifocal leukoencephalopathy. http://hum-molgen.org/NewsGen/03-2006/msg14.html - Genetic Association Information Network launched The NIH and Pfizer collaborate to unravel the genetic causes of common diseases over the next 3 years. http://hum-molgen.org/NewsGen/03-2006/msg13.html - Antibodies are the first wave of IGF-1R antagonists for cancer therapy At least six fully human or humanized antibodies against insulin-like growth factor-1 receptor (IGF-1R) are in early clinical development or close to phase I http://hum-molgen.org/NewsGen/03-2006/msg12.html - Glutamate Receptors And Schizophrenia Significant Association With Polymorphisms in the 5′ End of the N-Methyl-D-Aspartate Receptor Subunit Gene <I>GRIN1</I> http://hum-molgen.org/NewsGen/03-2006/msg11.html - Creatine and Minocycline Show Promise for Parkinson's Disease Preliminary study shows that creatine and minocycline warrant further investigation for the treatment of Parkinson's Disease. http://hum-molgen.org/NewsGen/03-2006/msg10.html - Contact Genetic News editors WWW: http://hum-molgen.org/editors.html E-mail: news@hum-molgen.org DIAGnostics - 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Genetics: 10 PhD studentships Max Planck Institute for Plant Breeding Research, Cologne, 50829, Germany http://hum-molgen.org/positions/predoctoral/0558.html - Neurology / Neuroscience: PhD position Max Planck Institute for Biophysical Chemistry, 37077 Göttingen http://hum-molgen.org/positions/predoctoral/0557.html - Call for Assistant News Editors To further strengthen our news section we are currently looking for: Assistant Editors for the HUM-MOLGEN News section http://hum-molgen.org/NewsGen/04-2003/msg01.html - Write a position announcement http://hum-molgen.org/flyer/positions.pdf 1) Set up account: http://hum-molgen.de/cgi-bin/positions.pl?register 2) Post position(s): http://hum-molgen.de/cgi-bin/positions.pl?login Biotechnical requests and sources http://hum-molgen.org/biotechnology Literature http://hum-molgen.org/literature/ - Sabaté et al. 2003. Adherence to Long-Term Therapies: Evidence for Action (WHO) Poor adherence attenuates optimum clinical benefits and therefore reduces the overall effectiveness of health systems http://hum-molgen.org/literature/03-2006/msg04.html - Brigelius-Flohé. Joost. 2006. Nutritional Genomics Impact on Health and Disease http://hum-molgen.org/literature/03-2006/msg02.html - Ziegler. Koenig. 2006. A Statistical Approach to Genetic Epidemiology Concepts and Applications http://hum-molgen.org/literature/03-2006/msg01.html Events in bioscience and medicine http://hum-molgen.org/meetings/ - Post event (free) http://hum-molgen.de/cgi-bin/meetings.pl?login Registry of Biomedical Companies (1271 active entries) http://hum-molgen.org/companies/ Mailing List Administration (Join or leave the list) http://hum-molgen.org/subscribe-na/ Feedback contact admin@hum-molgen.org Advertise at HUM-MOLGEN http://hum-molgen.org/flyer/advertise.pdf contact FS Zollmann (dialogue@hum-molgen.org) __________________________________________________________________________ Advances in Functional Genomics Conference & Exhibition San Francisco, CA - 25-26 April 2006 => http://hum-molgen.org/promotion-FG __________________________________________________________________________