HUM-MOLGEN archive: HUM-MOLGEN News Alert

__________________________________________________________________________ Cambridge Healthtech Institute's 2nd Annual Quantitative PCR, Microarrays and Biological Validation October 22 - 24, 2006 | Providence, Rhode Island => http://hum-molgen.org/promotion-qPCR - Gene expression profiling continues as the predominant tool to identify markers associated with disease or therapy targets - Gene expression data is prone to variance from experiment to experiment, lab to lab, platform to platform - Gene expression data must be validated with independent quantitative analysis tools __________________________________________________________________________ INTERNATIONAL COMMUNICATION FORUM IN HUMAN MOLECULAR GENETICS HUM-MOLGEN News Alert - August 17, 2006 - http://hum-molgen.org Genetic News by T.M. D'Souza, S. Chandler, T. Dalaya, K. Markey, J. Mill, La Merie S.L, R. Nemade, D. Sharma, F.S. Zollmann http://hum-molgen.org/NewsGen - Hunt For DNA Amplified In Cancers Uncovers Important Target Gene Gene amplification links growth controlling pathway from Drosophila to human cancers http://hum-molgen.org/NewsGen/08-2006/msg37.html - Scientists Reverse Evolution Half-Billion-Year-Old Gene is Reconstructed from Two Descendants http://hum-molgen.org/NewsGen/08-2006/msg36.html - Linkage Analysis Identifies a Novel Locus for Restless Legs Syndrome on Chromosome 2q in a South Tyrolean Population Isolate Research report of a genome-wide linkage scan of patients with Restless Legs Syndrome assessed in a population isolate of South Tyrol (Italy). http://hum-molgen.org/NewsGen/08-2006/msg35.html - Peters Plus Syndrome Is Caused by Mutations in B3GALTL, a Putative Glycosyltransferase Research show that Peters Plus is a monogenic, primarily single-mutation syndrome. http://hum-molgen.org/NewsGen/08-2006/msg34.html - Navajo Neurohepatopathy Is Caused by a Mutation in the MPV17 Gene Infantile, childhood, and classic forms of NNH have been described. http://hum-molgen.org/NewsGen/08-2006/msg33.html - New Autosomal Recessive Form of Stickler Syndrome Is Caused by a Mutation in the COL9A1 Gene Scientists describe a family of Moroccan origin that consists of four children with Stickler syndrome, six unaffected children, and two unaffected parents who are distant relatives (fifth degree). http://hum-molgen.org/NewsGen/08-2006/msg32.html - Mouse Study Finds That Mutant Enzyme Is Able To Help Protect DNA From Damage Research has shown that when DNA damage occurs, a key enzyme -- called ataxia telangiectasia mutated protein, or ATM -- becomes activated. http://hum-molgen.org/NewsGen/08-2006/msg31.html - Researchers Discover A Unique Pattern Of Gene Activity That Can Predict Liver Cancer Spread Researchers have found that a unique pattern of activity for genes in cells located in the tissue surrounding a liver tumor can accurately predict whether the cancer will spread to other parts of the liver or to other parts of the body. http://hum-molgen.org/NewsGen/08-2006/msg30.html - Tumors Use 'Hijacking' Trick To Evade Attack By Immune Cells Researchers have identified a potential mechanism by which tumors in mice escape attack from antitumor immune cells. http://hum-molgen.org/NewsGen/08-2006/msg29.html - New Findings Offer More Complete View Of Breast Cancer Gene Mutations In U.S. Population A large study funded by the National Institutes of Health today provided the clearest picture yet of the prevalence in the U.S. population of mutations in two genes associated with an increased risk of breast cancer. http://hum-molgen.org/NewsGen/08-2006/msg28.html - A Potential New Target For Antidepressants A potassium channel called TREK1 may represent a new target for antidepressant drugs. http://hum-molgen.org/NewsGen/08-2006/msg27.html - High-Resolution Fluorescence Imaging Two developments, expanding the potential applications of high-resolution fluorescence imaging, are published. http://hum-molgen.org/NewsGen/08-2006/msg26.html - Antiviral Protein Linked To Healthier Lungs Failure to produce enough of an antiviral protein called interferon-lambda may be linked to increased susceptibility to infection with rhinovirus - a common trigger for asthma exacerbations. http://hum-molgen.org/NewsGen/08-2006/msg25.html - Blocking Autoimmune Brain Inflammation A key factor that controls the development of brain inflammation is reported in two studies. http://hum-molgen.org/NewsGen/08-2006/msg24.html - Feeding immunity A link between zinc and a critical aspect of normal immune cell function is identified. http://hum-molgen.org/NewsGen/08-2006/msg23.html - Fighting Flies The first comprehensive molecular analysis of aggressive behavior in any laboratory species is reported in a study. http://hum-molgen.org/NewsGen/08-2006/msg22.html - One Recurrent Cause Of Mental Retardation Found Three papers describe a recurrent cause of mental retardation, which results from the deletion of a large segment of DNA from chromosome 17. http://hum-molgen.org/NewsGen/08-2006/msg21.html - How Neurons Sprout Like Trees Study reveals how some neurons establish and maintain a precise tree-like pattern of dendrites, the slim projections that carry electrical signals to and from neighbouring cells. http://hum-molgen.org/NewsGen/08-2006/msg20.html - Protein Folding Lost In Translation Scientists describe a new mechanism that could underlie certain neurodegenerative diseases. http://hum-molgen.org/NewsGen/08-2006/msg19.html - Survival Of The Well-Connected The survival of newly formed brain cells in the adult mouse depends on the input activity they receive. http://hum-molgen.org/NewsGen/08-2006/msg18.html - Arthritis Drug Helps Debilitating Inflammatory Disease A drug called anakinra brings marked improvement for neonatal-onset multisystem inflammatory disease. http://hum-molgen.org/NewsGen/08-2006/msg17.html - Imaging Study May Help Point Toward More Effective Smoking Cessation Treatments PET and MRI Scans show how even small amounts of nicotine can be addictive. http://hum-molgen.org/NewsGen/08-2006/msg16.html - Online Interventions as Medically Viable Options for Treatment A study has found that an Internet-based intervention program may prevent some high risk, college-age women from developing an eating disorder. http://hum-molgen.org/NewsGen/08-2006/msg15.html - Experimental Medication Kicks Depression in Hours Instead of Weeks Intravenous ketamine has the ability to relieve depression in as little as two hours. http://hum-molgen.org/NewsGen/08-2006/msg14.html - Are Air Freshners Hurting our Lungs? Chemical compound found in many air fresheners, toilet bowl cleaners, mothballs and other deodorizing products, may be harmful to the lungs. http://hum-molgen.org/NewsGen/08-2006/msg13.html - Contact Genetic News editors WWW: http://hum-molgen.org/editors.html E-mail: news@hum-molgen.org DIAGnostics - Clinical Research (professional requests) http://hum-molgen.org/clinical-research/ - Post diagnostic request / call for collaboration http://hum-molgen.org/diagnostic-posting or contact admin@hum-molgen.org Biotechnical requests and sources http://hum-molgen.org/biotechnology - Post request or source http://hum-molgen.org/biotechnical-request-posting Biomedical Positions http://hum-molgen.org/positions/ - Cardiovascular Research: Postdoctoral Research Associate: Stem Cell Biology/Hematopoiesis/Vascular Biology University of Wisconsin, Madison, WI, 53706, United States of America http://hum-molgen.org/positions/postdocs/2628.html - Computational Genetics / Bioinformatics: Marie Curie-sponsored Studentship for post graduate and < 4 years research experience INRA, Jouy en Josas, France, JOUY-EN-JOSAS, 78350, France http://hum-molgen.org/positions/predoctoral/0561.html - Write a position announcement http://hum-molgen.org/flyer/positions.pdf 1) Set up account: http://hum-molgen.de/cgi-bin/positions.pl?register 2) Post position(s): http://hum-molgen.de/cgi-bin/positions.pl?login Literature http://hum-molgen.org/literature/ Events in bioscience and medicine http://hum-molgen.org/meetings/ - Post event (free) http://hum-molgen.de/cgi-bin/meetings.pl?login Registry of Biomedical Companies (1266 active entries) http://hum-molgen.org/companies/ Mailing List Administration (Join or leave the list) http://hum-molgen.org/subscribe-na/ Feedback contact admin@hum-molgen.org Advertise at HUM-MOLGEN http://hum-molgen.org/flyer/advertise.pdf contact FS Zollmann (dialogue@hum-molgen.org) __________________________________________________________________________ Cambridge Healthtech Institute's 2nd Annual Quantitative PCR, Microarrays and Biological Validation October 22 - 24, 2006 | Providence, Rhode Island => http://hum-molgen.org/promotion-qPCR - Gene expression profiling continues as the predominant tool to identify markers associated with disease or therapy targets - Gene expression data is prone to variance from experiment to experiment, lab to lab, platform to platform - Gene expression data must be validated with independent quantitative analysis tools Biological research is costly - both in time and resources - making the careful design and validation of gene expression experiments to generate useful data for diagnostics, target identification, screening, and genotyping applications critical. Researchers are still confronted with difficult questions after completing any expression profiling experiment - how to validate and standardize the data that has been generated. Learn from seasoned and savvy researchers capturing the complete biological story. __________________________________________________________________________ -- | INTERNATIONAL COMMUNICATION FORUM IN HUMAN MOLECULAR GENETICS | HUM-MOLGEN - http://hum-molgen.org | (C) 1994-2006