HUM-MOLGEN archive: Second Workshop Neurogenetics in Germany

Dear HUM-MOLGENeticists, The following document contains the Program of the Second Workshop Neurogenetics in Germany and a summary of the abstracts. All abstracts are available on our WWW in the near future (I will inform you). For more information please contact M. Graeber <LABMOLNP@neuropathologie.medizin.uni-muenchen.d400> More information about meetings and workshops are available at: http://www.informatik.uni-rostock.de/HUM-MOLGEN/anno/meetings.html Best wishes, Frank S. Zollmann ************************************************************** Program of the Second Workshop Neurogenetics in Germany/ Annual Meeting of the German Society of Neurogenetics ************************************************************** Munich, October 19-21, 1995 Invited Speakers: K.H. Fischbeck, Philadelphia M. Koenig, Strasbourg A.P. Monaco, Oxford L. Ozelius, Boston H.H. Ropers, Nijmegen A.M. Saunders, Durham T. Siddique, Chicago Supported by the German Research Foundation Organizers: M. Graeber, Munich, and U. Muller, Giessen ************************************************************** Thursday, October 19, 1995 18:00 Welcome Reception 19:00 Membership Assembly of the German Society of Neurogenetics Friday, October 20, 1995 8.15 Introduction Morning session I (Chair: H.H. Ropers) 8.30 ApoE and Alzheimer's disease A.M. Saunders (Durham/U.S.A.) 9.15 Non-specific X-linked mental retardation H.H. Ropers (Nijmegen/Netherlands) 10.00 15 min Break Morning session II (Chair: H.A. Kretzschmar) 10.15 Genetics of dystonia L. Ozelius (Boston/U.S.A.) 11.00 Prion diseases H.A. Kretzschmar (Gottingen) 11.45 15 min Break Afternoon session I (Chair: L. Ozelius) 12.00 Dopa-responsive Dystonia (DRD): 4 new mutations of the GTP cyclohydrolase gene in British patients O. Bandmann, C.D. Marsden and A.E. Harding (London/U.K.) 12.20 Cerebellar ataxia, mental retardation and retinitis pigmentosa associated with T8,993G mitochondrial DNA point mutation E. Wilichowski, K. Brockmann, C. Korenke, A. Renneberg, J. Frahm and F. Hanefeld (Gottingen, Unna-Konigsborn) 12.40 Marinesco-Sjogren-Syndrom: neuro-myopathischer Subtyp? J.-U. Walther, W. Muller-Felber und M. Jensen (Munchen) 13.00-14.00 Lunch break Afternoon session II (Chair: T. Siddique) 14.00 Neurofibromatosis type 2 protein merlin is highly expressed in human fibroblasts and linked to the plasma membrane M. Kressel and B. Schmucker (Erlangen) 14.15 Isolation and characterization of two human genes similar to the region-specific homeotic Drosophila gene SPALT which show expression in the developing and adult human brain J. Kohlhase, R. Schuh, H. Jackle, B. Schroeder, W. Schulz-Schaeffer, H.A. Kretzschmar, A. Kohler, U. Muller, E. Burkhard, M. Raab-Vetter, W. Engel and R. Stick (Gottingen) 14.30 Mouse models created by gene targeting to study mid- hindbrain development W. Wurst, V. Blanquet, M. Hanks and A.L. Joyner (Toronto/Canada, Oberschleissheim) 14.45 A retroviral vector for tetracycline-regulatable expression of heterologous genes W. Paulus, I. Baur, F.M. Boyce, X.O. Breakefield and S.A. Reeves (Boston/U.S.A.) 15.00 Neurotransmitter mediated Ca2+ signalling in human glioma and neurocytoma cells P. Weydt, S. Patt and H. Kettenmann (Berlin-Buch) 15.15 The importance of brain banks for neurogenetic research M.B. Graeber, S. Kosel, R. Egensperger, N.M. Schnopp and P. Mehraein (Munchen) 16.00-18.00 Poster sessions P1 McLeod neuroacanthocytosis: An underdiagnosed syndrome? M. Oechsner, G. Winkler, A. Danek, M. Ho and A.P. Monaco (Hamburg, Munchen, Oxford/U.K.) P2 Hereditare Stammgangliendegeneration mit dominantem Erbgang - eine Stammbaumstudie M. Hund, P. Ludemann und E.B. Ringelstein (Munster, New York/U.S.A.) P3 Genetic linkage studies in autosomal dominant parkinsonism: evaluation of candidate genes T. Gasser, Z.Wszolek, B. Muller and A. Supala (Munchen, Omaha/U.S.A., Hamburg) P4 Delineation of the XDP gene within a small region of Xq13.1 and characterization of two candidate genes G. Haberhausen, N. Brockdorff, M. Fontes, A.P. Monaco and U. Muller (Giessen, Harrow/U.K., Marseille/France, Oxford/U.K.) P5 A contig in Xq13.1 U. Peters, G. Haberhausen, H. Muth, A. Kohler, A.P. Monaco and U. Muller (Giessen, Oxford/U.K.) P6 Distribution of G5460A mutant mtDNA in parkinsonian brain N.M. Schnopp, S. Kosel, R. Egensperger, P. Mehraein and M.B. Graeber (Munchen) P7 NADH dehydrogenase and CYP2D6 genotypes in Parkinson's disease S. Kosel, N.M. Schnopp, R. Egensperger, P. Mehraein and M.B. Graeber (Munchen) P8 Identical twins with Huntington's disease: differences in cerebral glucose metabolism and clinical manifestation A. Weindl, P. Bartenstein, R. Wenzel, M. Rehm, S. Spiegel, T. Meitinger, M. Schwaiger and B. Conrad (Munchen) P9 SOD1 Punktmutation in einer Familie mit ALS B. Bereznai, G.D. Borasio, A. Winkler and T.Gasser (Munchen) P10 Die spinale Muskelatrophie Typ Kennedy (XSBMA) in der Differentialdiagnose von Motoneuronerkrankungen W. Kress, B. Halliger-Keller und T. Grimm (Wurzburg) P11 Autosomal dominant cerebellar ataxia and CAG repeat expansion C. Zuhlke, W. Klostermann, K. Wessel and E. Schwinger (Lubeck) P12 Gen-Konversion bei Dystrophia myotonica V. Otto, P. Vieregge, M. Greiwe und P. Steinbach (Lubeck, Ulm) P13 Association between apolipoprotein E genotype and neuropathological phenotype in sporadic Alzheimer's disease R. Egensperger, S. Kosel, P. Mehraein and M.B. Graeber (Munchen) P14 Apolipoprotein-E-Genotyp und Alzheimer-Krankheit: Beziehung zu relativem Risiko, Erkrankungsalter und Verlauf A. Kurz, N. Lautenschlager, R. Marquard, D. Mosch, R. Busch, R. Egensperger, M.B. Graeber, K. Altland and U. Muller (Munchen, Giessen) P15 Investigations on the point mutations at nt5460 of the mtDNA in different neurodegenerative and neuromuscular diseases B. Janetzky, C. Schmid , P. Riederer and H. Reichmann (Wurzburg) Saturday, October 21, 1995 Morning session I (Chair: U. Muller) 8.30 Genetics of motor neuron degeneration in mice and man T. Siddique (Chicago/U.S.A.) 9.15 Autosomal-recessive ataxias M. Koenig (Strasbourg/France) 10.00 15 min Break Morning session II (Chair: A.P. Monaco) 10.15 Trinucleotide repeats and neurological disease K.H. Fischbeck (Philadelphia/U.S.A.) 11.00 McLeod Syndrome A.P. Monaco (Oxford/U.K.) 11.45 15 min Break Afternoon session I (Chair: A.M. Saunders) 12.00 Candidate gene approach in panic disorder: the adenosine A1 receptor J. Deckert, M. Nothen, W. Maier, P. Franke, J. Fritze, H. Beckmann, H. Ren, G.L.Stiles and P. Propping (Bonn, Mainz, Frankfurt, Wurzburg, Durham/U.S.A.) 12.20 Molecular genetic studies of variation in dopamine and serotonin receptor genes M.M. Nothen, S. Cichon, J. Erdmann, D. Shimron-Abarbanell and P. Propping (Bonn) 12.40 Eine Mutation im CHRNA4-Gen als Ursache einer idiopathischen Epilepsie O. Steinlein (Bonn) 13.00-14.00 Lunch break Afternoon session II (Chair: K.H. Fischbeck) 14.00 DNA methylation and triplet repeat stability D. Wohrle, M. Wolf, D. Glaser, S. Schwemmle and P. Steinbach (Ulm) 14.15 Phenotype and genotype in persistent mirror movements A. Danek, J. Wendeborn and J. Hermsdorfer (Munchen) 14.30 Eye tracking dysfunction as phenotypic marker in linkage studies with schizophrenia R. Lencer, V. Arolt, S. Purmann, A. Nolte, B. Muller, M. Schurmann and E. Schwinger (Lubeck, Hamburg) 14.45 Altered interleukin-6 secretion capacity of monocytes in narcoleptic patients D. Hinze-Selch, T. Wetter, Y. Zhang, H. Lu, F. Holsboer and T. Pollmacher (Munchen) 15.30-17.00 Poster sessions P16 Geniospasm: a type of essential tremor? A. Danek and T. Meitinger (Munchen) P17 Linkage analysis and mutation screening in two large families with non-syndromic X-linked mental retardation E. Holinski-Feder, A. Golla, I. Rost, H. Seidel, T. Strom, O. Rittinger, K. Wilke, T. Meitinger and A. Meindl (Munchen, Salzburg/Osterreich, Heidelberg) P18 Phylogeny of the human dopamine D2 receptor gene (DRD2) and investigation of its association with alcoholism U. Finckh, M. Giraldo-Velasquez, G. Otto, O. von Widdern, T. Sander, L.G. Schmidt, H. Rommelspacher and A. Rolfs (Berlin, Rostock) P19 Despite different location pattern, similar p53 gene mutation frequency in pediatric and adult glioblastoma U. Sure, M. Hegi, J. Lubbe, A. von Deimling and P. Kleihues (Aachen, Zurich/Schweiz) P20 Untersuchungen der mitochondrialen DNA bei MS- Patientinnen U. Mayr-Wohlfart, G. Rodel, C. Paulus und A. Henneberg (Ulm, Dresden) P21 Molecular genetics of human prion diseases in Germany O. Windl, A. Giese, T. Jacobsen, T. Bogumil, M. Neumann, T. Weber, S. Poser and H. Kretzschmar (Gottingen) P22 Informative crossover refines mapping of the CADASIL disease locus M. Dichgans, M. Mayer, B. Muller, A. Straube and T. Gasser (Munchen) P23 Molecular analysis in Charcot-Marie-Tooth (CMT) disease and hereditary neuropathy with liability to pressure palsies (HNPP) K.D. Bathke, D. Lorek, T. Liehr, A. Ekici, E. Nelis, C. Van Broeckhoven, H. Grehl, D. Claus, B. Neundorfer and B. Rautenstrauss (Erlangen, Antwerpen/Belgium) P24 Molekulargenetische Diagnostik der Adrenomyeloneuropathie M. Vorgerd, S. Fuchs, M. Tegenthoff und J.-P. Malin (Bochum, Hamburg) P25 Coping-Verhalten von Risikopersonen fur spatmanifeste neuro-degenerative Erkrankungen bezuglich des Ergebnisses der pradiktiven DNA-Analyse T. Haase und F. Kreuz (Dresden) P 26 Role of transcription factors in microglial activation: the cAMP responsive element binding protein (CREB) is involved in microglial activation in vivo J. Gehrmann, R.B. Banati, F. Beermann, E. Hummler, J. Blendy, G. Schutz, G.W. Kreutzberg und A. Aguzzi (Zurich und Epalinges/Schweiz, Heidelberg, Martinsried) 17.00 End of meeting Annotation: The German Society of Neurogenetics was founded in 1994. Its main objective is the enhancement of scientific exchange between all those disciplines that address questions on the genetics of normal and abnormal function of the nervous system. Consequently, its members come from many diverse fields of scientific enquiry such as Biophysics, Human Genetics, Cell Biology, Neuroanatomy, Neurochemistry, Neurosurgery, Neurology, Neuropathology and Psychiatry. The Society organizes yearly workshops to discuss scientific breakthroughs in the field. Here, international invited speakers guarantee the highest possible scientific standard. Furthermore, the society issues at least two yearly newsletters. While the first two newsletters were written in German, future communications will be in English. The statutes of the society, copies of all newsletters and a registration form can be obtained at: http://www.med.uni-giessen.de/genetik/dgng.html