Since it's release, the first edition of Human Molecular Genetics has become the standard reference source for over 27.000 individuals and is widely used as an undergraduate teaching text around the world. However, in the intervening period since its publication in 1996, there have been a number of significant changes in our understanding of the principles described in the book. The second edition, whilst retaining the well-regarded structure of the first edition, addresses these by incorporating a wealth of new data and features.
DNA structure and gene expression
Chromosomes in cells
Genes in pedigrees
Cell-based DNA cloning
Nucleic acid hybridization assays
PCR, DNA sequencing and in vitro mutagenesis
Organization of the human genome
Human gene expression
Instability of the human genome: mutation and DNA repair
Physical and transcript mapping
Genetic mapping of mendelian characters
Genetic mapping of complex characters
Our place in the tree of life
Identifying human disease genes
Genetic testing in individuals and populations
Complex diseases: theory and results
Studying human gene structure, expression and function using cultured cells and cell extracts
Genetic manipulation of animals
Gene therapy and other molecular genetic-based therapeutic approaches
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