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virtual library in human genetics and molecular biology

Crystal structure of NH3-dependent NAD⁺ synthetase from Bacillus subtilis

M. Rizzi, C. Nessi, A. Mattevi, A. Coda, M. Bolognesi and A. Galizzi

Pages: 5125 - 5133

Crystal structure of enoyl-coenzyme A (CoA) hydratase at 2.5 Å resolution: a spiral fold defines the CoA-binding pocket

CK. Engel, M. Mathieu, JP. Zeelen, JK. Hiltunen

Pages: 5135 - 5145

The mechanism of protein splicing and its modulation by mutation

MQ. Xu and FB. Perler

Pages: 5146 - 5153

Site-directed mutagenesis and structural interpretation of the nidogen binding site of the laminin [gamma]1 chain

E. Poschl, U. Mayer and R. Timpl

Pages: 5154 - 5159

Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase II[alpha]

MA. Kelliher and P. Leder

Pages: 5160 - 5166

CrmA expression in T lymphocytes of transgenic mice inhibits CD95 (Fas/APO-1)-transduced apoptosis, but does not cause lymphadenopathy or autoimmune disease

KGC. Smith, A. Strasser and DL. Vaux

Pages: 5167 - 5176

A slow sustained increase in cytosolic Ca²⁺ levels mediates stalk gene induction by differentiation inducing factor Dictyostelium

P. Schaap

Pages: 5177 - 5183

The Aspergillus FlbA RGS domain protein antagonizes G protein signaling to block proliferation and allow development

JH. Yu, J. Wieser and TH. Adams

Pages: 5184 - 5190

Status of YopM and YopN in the Yersinia Yop virulon: YopM of Y. enterocolitica is internalized inside the cytosol of PU5-1.8 macrophages by the YopB, D, N delivery apparatus

A. Boland, MP. Sory, M. Iriarte, C. Kerbourch, P. Wattiau and GR. Cornelis

Pages: 5191 - 5201

In vivo membrane assembly of the E. coli polytopic protein, melibiose permease, occurs via a Sec-independent process which requires the protonmotive force

M. Bassilana and C. Gwizdek

Pages: 5202 - 5208

Targeting of signal sequenceless proteins for export in Escherichia coli with altered protein translocase

WA. Prinz, C. Spiess

Pages: 5209 - 5217

The [beta]-amyloid domain is essential for axonal sorting of amyloid precursor protein

PJ. Tienari, B. De Strooper, E. Ikonen and CG. Dotti

Pages: 5218 - 5229

The tyrosine-based lysosomal targeting signal in lamp-1 mediates sorting into Golgi-derived clathrin-coated vesicles

S. Honing

Pages: 5230 - 5239

Human palmitoyl protein thioesterase: evidence for lysosomal targeting of the enzyme and disturbed cellular routing in infantile neuronal ceroid lipofuscinosis

E. Hellsten, J. Vesa, VM. Olkkonen

Pages: 5240 - 5245

Misdivision analysis of centromere structure in maize

E. Kaszas and JA. Birchler

Pages: 5246 - 5255

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002

GJ. Brun and RT. Abraham

Pages: 5256 - 5267

The role of proteolysis in cell cycle progression in Schizosaccharomyces pombe

H. Yamano, J. Gannon and T. Hunt

Pages: 5268 - 5279

The proteolysis of mitotic cyclins in mammalian cells persists from the end of mitosis until the onset of S phase

M. Brandeis and T. Hunt

Pages: 5280 - 5289

Oncoprotein 18 is a phosphorylation-responsive regulator of microtubule dynamics

U. Marklund, N. Larsson, HM. Gradin, G. Brattsand

Pages: 5290 - 5298

Mutation of a Src phosphorylation site in the PDGF [beta]-receptor leads to increased PDGF-stimulated chemotaxis but decreased mitogenesis

K. Hansen

Pages: 5299 - 5313

Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents

A. Knebel, HJ. Rahmsdorf, A. Ullrich and P. Herrlich

Pages: 5314 - 5325

N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases

H. Miki, K. Miura

Pages: 5326 - 5335

PPAR[alpha] and PPAR[gamma] activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene

K. Schoonjans, J. Peinado-Onsurbe

Pages: 5336 - 5348

MDMX: a novel p53-binding protein with some functional properties of MDM2

A. Shvarts, WT. Steegenga, N. Riteco, T. van Laar, P. Dekker, M. Bazuine, RCA. van Ham, W. van der Houven van Oordt, G. Hateboer

Pages: 5349 - 5357

Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development

L. Sun, A. Liu

Pages: 5358 - 5369

Purification and biochemical heterogeneity of the mammalian SWI-SNF complex

W. Wang, J. Cote

Pages: 5370 - 5382

Hoxb-2 transcriptional activation in rhombomeres 3 and 5 requires an evolutionarily conserved cis-acting element in addition to the Krox-20 binding site

C. Vesque

Pages: 5383 - 5396

High resolution mapping of E. coli transcription elongation complex in situ reveals protein interactions with the non-transcribed strand

M. Guerin, M. Leng and AR. Rahmouni

Pages: 5397 - 5407

A nuclear role for the Fragile X mental retardation protein

RA. Fridell and BR. Cullen

Pages: 5408 - 5414

Novel exploitation of a nuclear function by influenza virus: the cellular SF2/ASF splicing factor controls the amount of the essential viral M2 ion channel protein in infected cells

SR. Shih

Pages: 5415 - 5427

Cis-element, oriR, involved in the initiation of (-) strand poliovirus RN: a quasi-globular multi-domain RNA structure maintained by tertiary ('kissing') interactions

EV. Pilipenko, KV. Poperechny, SV. Maslova and VI. Agol

Pages: 5428 - 5436

The yeast protein Arc1p binds to tRNA and functions as a cofactor for the methionyl- and glutamyl-tRNA synthetases

G. Simos, A. Segref, F. Fasiolo

Pages: 5437 - 5448

Influence of DNA geometry on transcriptional activation in Escherichia coli

S. Dethiollaz, P. Eichenberger and J. Geiselmann

Pages: 5449 - 5458

Counteracting the mutagenic effect of hydrolytic deamination of DNA 5-methylcytosine residues at high temperature: DNA mismatch N-glycosylase Mig.Mth of the thermophilic archaeon Methanobacterium thermoautotrophicum THF

JP. Horst and HJ. Fritz

Pages: 5459 - 5469

A purified mariner transposase is sufficient to mediate transposition in vitro

DJ. Lampe and HM. Robertson

Pages: 5470 - 5479

he EMBO Journal is published 24 times a year by Oxford University Press on behalf of the European Molecular Biology Organisation.

The papers listed above will appear in the 1st October issue.

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