JLG Drug & Fine Chemicals Enterprises of Canada

Genomics, Proteomics & Metabolomics in Drug Discovery
Port Coquitlam
Canada
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Description:

Discoveries in Drugs (Biopharma and Orthopharma) & Nutraceuticals: mRNA vaccines, protein-like/fructan-like/longchain fatty acid polymers (PLPs, FLPs, LFPs), Bioactive Proteases Up/Down Regulated with PNA-B12 Technology in Rumen Protein Nutrition.Portfolio:

 Portfolio: drug candidates

•  Adaptogenics
• Cardionetics - Water Hyacinth
• Milk Food Proteins & drug discovery
• VitD agonists

Introduction.

As a news item, the latest reports for sequencing genomes like the human genome it is clocked at 10 minutes with what is called the MGI Tech's sequencer model, the DNBSEQ-T7+.  We presume this hi-throughput is not only true for the time but also capacity in sample handling. This will be employed with what is referred to in bioinformatics as new generation sequencing (NGS) together with data analysis.

These protocols would have the task or capacity to assemble genomes together, identify mutations and including classifying mutant pathogen strains and with high precision.  This can lead to further work for vaccine development including for tropica climes and can even be also applied for ensuring food safety.

At Skye Blue we are still negotiating use of our exclusive and proprietary reagent analyte, a detergent dye chromophoric molecule to separate and quantify and ID the protein analytes like biopharma and further down the road sequencing with extreme speed, accuracy and capacity, proteins utilizable for drug discovery and biopharmaceutical drug design or for mRNA-based vaccines and more conventional type vaccines.

Polymer-Like Polymers- Proetein-Like, Fructan-Like, Long-chain Fatty Acid Polymers.

There are new protein-like polymers (PLPs), a new drug material polymer which arrived just awhile ago (See ref.: JM Mesfin et al., 2025, Protein-like Polymers Targeting Keap1/Nrf2 as Therapeutics for MI. Adv. Mater. 37 2417885 17pp.).

Two e. g. currently to be used possibly for clinical treatment by Skye Blue are SCI-related conditions like rheumatoid arthritis (RA), still speculative, and other called heart attack or myocardial infarction (MI) on its way to preclinical trials involving the inflammatory response and pharma design as globular hydrophobic cored and side-chained with bioactive peptide designed strands that act directly on the domains of the so-called Kelch protein otherwise reacting with and deactivating Nrf2, which down the road, results in further steps including activation of the inflammatory response and so forth, which constitutes the aetiology of the RA condition, viz. including erosion of the cartillage and bone of the human extremeties.  In the case of RA the culprit is so-called reactive oxygen species (ROS), superoxide and H2O2, produced by the enzyme called NOX4 (NAPH oxidase 4); apparently the NOX4 factor is not only clearly established yet by the aetiology with RA.  Perhaps the Nrf2 story and its inflammatory-related aetiology is more of a drug target as is the case in MI.

As a footnote, here the conception of polymer extension to impact on drug delivery whether it be a globular protein affecting the inflammatory condition like our PLP-specific drug with Nrf2 and further speculation of fructan as a sugar of greater length or MW as a potential potent nutraceutical and another fact of the lower gut being a potent immunological-related organ of significance to SCI and with its absorption yet through and into the gut lining to act there in some way is our hypothesis.  And yet another e. g. called conjugated or connected fatty acids called conjugated linoleic acid (CLA) of known nutraceutical potency is also a possible theory for clinical drug discovery and delivery.

Rumen Protein Digestion.

Another area of research opening upas we speak is peptide research regards the leader sequence, the typical peptide length or its super elongation and the rate of uptake of its amino acids and incorporation into microbial cell biomass protein in rumen digestive processing in large ruminant livestock for meat and dairy with respect to the membrane bound transport system for these peptides.

Preparation from feed manufacturing will be dependent on clean bioreactor processing the bulk tonnage capacity using gene edited yeast hosts that have been processed as DNA-free biomass or non-GMO labelled protein supplements and that have been treated to slow their breakdown as biomass and protein to facilitate uptake into utilizing microbial cells with digestion in the rumen stomach's digestive process.  The amino acid (AA) composition of superelongated peptides will depend on their limitations in microbial protein synthesis which in turn be reflected on the essentiality to the host of the AA profile of the resulting nutrient biomass from microbial flows, in addition to the escape component untouched by microbial digestion from dietary sourced feed protein.

To continue with one last other e. g. in a theory called Protein-Energy Theory in rumen protein nutrition for livestock and the role with it of bioactive peptides as cofactoring 'chaperones' with the protein synthesizing machinery acting in rumen microbial cells for synthesis of microbial cell protein (MCP) in rumen biomass over and above the escape of the rest of dietary protei going through that part of the gut.  The idea here is to use TF technology with PNA-B12 carriered facilitation through the microbial cell wall-cell membranes to up or down regulate our GROs and their peptide content for 'catalytic' MCP synthesis to boost protein outflow from the rumen gut together with escape protein outflow direct from the diet.

Oxidative Detergent Enzymes for Textiles and as Drugs.

Oxidative Biozymes as textile cleaning detergents and molecular drug scubbers against for plaques for cardiac health, the latter being a plausible drug agents. As a precursor the author has had contact with a French-speaking researcher from McGill University Biochem.'s department on a folate-dependent enzyme that is symmetrically circular with multiple active sites and passess substrate cyclically.  We hypothesize that a "close-call diffusive" mechanism holds for our "rotary biozyme model" passing intermediates between tertiary subunits as it oxidizes it. 

(c) D. A. Flores.  Skye Blue (SB) Press Corporation.  Port Coquitlam BC Canada  V3B 1G3. 

Last update of this entry: July 27, 2026