home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Coding Gene Regulation

 
  December, 13 2007 10:18
your information resource in human molecular genetics
 
     

Three papers published online Nature Cell Biology analyse a component of chromatin - the complex of DNA and protein that makes up chromosomes - and identify two new modifications that expand the 'chromatin code'. The research also shows that a variant of this component mediates 'epigenetic memory' - a process of key importance to cloning.

 

The DNA of a human cell totals about two meters. To prevent the vast stretches of DNA turning into a tangle, the genome is spooled tightly around protein complexes called histones. Recent research has shown that histones also regulate gene activity and a growing number of reversible chemical modifications of these proteins -- collectively called the 'chromatin code' -- have been uncovered and found to regulate gene expression.

 

Roland Schüle and colleagues identify a new letter in the alphabet of the chromatin code in the form of phosphorylation of a histone called H3 and show that this letter allows genes packaged around the phosphorylated H3 to be activated. In a related paper, Michael Rudnicki and colleagues unravel how Pax7, a key regulator of muscle gene activity, works. By recruiting an enzyme that adds another letter, a methyl-group, to H3 it regulates genes that govern the differentiation of certain stem cells into muscle cells. Finally, John Gurdon and colleagues show how a gene maintains its activity status during the cloning procedure, when a nucleus from a differentiated donor tissue is transplanted into an egg. The memory of the gene status is dependent on a specific variant of H3 called H3.3. Remarkably, this memory was shown to be maintained while the cells of the egg multiply twenty four times.

Author contacts:

Roland Schüle (ZKF, Uniklinik-Frauenklinik, Freiburg, Germany)
E-mail: roland.schuele@uniklinik-freiburg.de

Michael Rudnicki (Ottawa Health Research Institute, Ontario, Canada)
E-mail: mrudnicki@ohri.ca

John Gurdon (Wellcome Trust/Cancer Research UK Gurdon Institute, Cambridge, UK)
E-mail: j.gurdon@gurdon.cam.ac.uk

Abstracts available online:
Paper 1.
Paper 2.
Paper 3.

(C) Nature Cell Biology press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.