home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Changing Rates Of Genetic Subtypes Of Prader–Willi Syndrome In The UK

  December, 21 2006 1:28
your information resource in human molecular genetics
Changing Rates Of Genetic Subtypes Of Prader–Willi Syndrome In The UK

Joyce E Whittington, Jill V Butler and Anthony J Holland

Published in European Journal of Human Genetics (2007) 15, 127–130.

Department of Psychiatry, Section of Developmental Psychiatry, University of Cambridge, Cambridge, UK


The genetically determined neurodevelopmental disorder, Prader–Willi syndrome (PWS), has two main genetic subtypes: a 15q11–q13 deletion affecting the paternally inherited chromosome 15 and chromosome 15 maternal uniparental disomy (mUPD) in which two maternal copies of chromosome 15 are inherited but no paternal copy. It has been accepted that these subtypes occur in approximately 70 and 25% of cases, respectively. This is the first report of a greater proportion (50%) of those with PWS due to mUPD in children presently under 5 years living in the UK. Increasing maternal age at conception is likely to explain the changing proportions in this generation of mothers.


Dr J. E. Whittington, Department of Psychiatry, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge CB2 2AH, UK. E-mail: jew1000@cam.ac.uk

Full article available online.

(C) European Journal of Human Genetics.

Posted by: Tressie Dalaya.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2018 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.