home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

New Antibacterial Targets?

 
  December, 6 2006 9:39
your information resource in human molecular genetics
 
     
Small molecules that bind to segments of RNA called riboswitches could represent a novel class of antibiotics according to a report in the January issue of Nature Chemical Biology.

Small segments of RNA called riboswitches can control gene expression in response to the presence of bacterial metabolic products. The lysine riboswitch controls the biosynthesis of lysine, an essential amino acid for bacteria. Ronald Breaker and colleagues created small molecules that are chemically similar to lysine. They found that some of these lysine 'analogs' bind to the lysine riboswitch and as a result prevent lysine biosynthesis thereby stopping bacterial growth.

The authors suggest that rationally targeting riboswitches -- which are involved in sensing many critical bacterial metabolites -- could provide a new class of antibiotics.

Author contact:

Ronald R Breaker (Yale University, New Haven, CT, USA)
E-mail: ronald.breaker@yale.edu

Abstract available online.

(C) Nature Chemical Biology press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.