home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

How Primary Tumours Prepare Lung For Invasion

 
  December, 6 2006 9:34
your information resource in human molecular genetics
 
     
Primary tumours prepare the lung for invasion by inducing factors that guide migration of both inflammatory and tumour cells to the lung according to a study in the December issue of Nature Cell Biology.

Many solid tumours develop through a process of metastasis, where the cancer spreads from the primary site to other places in the body. Metastasis reduces both the chances of treatment and underlies late stage symptoms, yet research into the process is in its infancy.

Sachie Hiratsuka and colleagues studied tumour-bearing mice and found that certain proteins called chemokines are induced in the lung by a set of factors secreted by the primary tumour. The chemokines induce migration of both inflammatory and tumour cells to the lung. An amplifying circuit is created between the primary tumour and the premetastatic tissue to facilitate metastatic tumour invasion. Interrupting this circuit of signals between the primary tumour and cells in the lung efficiently blocked lung metastases in mice.

Blocking migration of tumour cells to the metastatic sites at an early stage presents a promising clinical avenue to prevent the spread of cancer.

Author contact:

Yoshiro Maru (Women's Medical University School of Medicine, Tokyo, Japan)
E-mail: ymaru@research.twmu.ac.jp

Abstract available online.

(C) Nature Cell Biology press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.