home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Drug Promise For Renal Disease

  December, 6 2006 9:19
your information resource in human molecular genetics
A drug that alters renal cell proliferation may prove a useful treatment for polycystic kidney disease, a mouse study suggests in a paper published online by Nature.

Oxana Ibraghimov-Beskrovnaya and colleagues found that (r)-roscovitine, a drug that interferes with cell proliferation, slows disease progression in two mouse models of autosomal dominant polycystic kidney disease (ADPKD). A single pulse treatment produced robust, long-lasting effects in mice, and was effective against cysts found in different parts of the kidney.

Human ADPKD is a late-onset genetic disorder without effective treatment. Fluid-filled cysts form in the kidney tubules, leading to renal failure. The researchers suspect that the cells making up the hair-like cilia that line the kidney tubules have abormal cell cycles. (r)-roscovitine alters this by inhibiting enzymes called cyclin-dependent kinases.


Oxana Ibraghimov-Beskrovnaya (Genzyme Corporation, Framingham, MA, USA)
E-mail: oxana.beskrovnaya@genzyme.com

Abstract available online.

(C) Nature press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.