Jefferson scientists suggest potential mechanism underlying the origin of colon cancer
Researchers may have figured out one way in which a mutation in a gene thought to be responsible for colon cancer may actually cause the disease. They showed in the laboratory that this gene, APC, normally limits the expression of a protein, survivin, which prevents stem cells in the colon from dying. When APC is altered, survivin works overtime and stem cells in the colon, instead of dying, grow, resulting in cancer.
Thomas Jefferson University
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