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Mucosal HIV Vaccine Effective In Macaques

  December, 3 2001 9:38
your information resource in human molecular genetics
Mucosal surfaces, such as the lining of the mouth and anus, are a portal of entry for HIV infection, particularly since they lead to the intestine where the conditions for the virus to replicate are optimal. Thus, developing a vaccine that would prevent HIV entry through mucosal surfaces is paramount to fighting the AIDS epidemic.

A team of researchers lead by Jay Berzofsky at the US National Cancer Institute compared the protective ability of a vaccine given subcutaneously (s.c.) and intrarectally to macaque monkeys (Nature Medicine). The vaccine was a combination of peptides based on the HIV virus known to stimulate antibodies and other cytotoxic cells. The scientists found that when they administered the vaccine (plus an adjuvant to stimulate a response) at the mucosal surface of the rectum it was more effective at preventing infection with simian/human immunodeficiency virus (SHIV) than when the same vaccine was administered s.c.

Author contact:
Dr Jay A. Berzofsky
Molecular Immunogenetics and Vaccine Research Section
Metabolism Branch
National Cancer Institute
Bethesda, MD
Telephone: +1 301 496 6874
Fax: +1 301 496 9956
Email: berzofsk@helix.nih.gov

(C) Nature Medicine press release.

Message posted by: Trevor M. D'Souza

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