home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Mucosal HIV Vaccine Effective In Macaques

 
  December, 3 2001 9:38
your information resource in human molecular genetics
 
     
Mucosal surfaces, such as the lining of the mouth and anus, are a portal of entry for HIV infection, particularly since they lead to the intestine where the conditions for the virus to replicate are optimal. Thus, developing a vaccine that would prevent HIV entry through mucosal surfaces is paramount to fighting the AIDS epidemic.

A team of researchers lead by Jay Berzofsky at the US National Cancer Institute compared the protective ability of a vaccine given subcutaneously (s.c.) and intrarectally to macaque monkeys (Nature Medicine). The vaccine was a combination of peptides based on the HIV virus known to stimulate antibodies and other cytotoxic cells. The scientists found that when they administered the vaccine (plus an adjuvant to stimulate a response) at the mucosal surface of the rectum it was more effective at preventing infection with simian/human immunodeficiency virus (SHIV) than when the same vaccine was administered s.c.

Author contact:
Dr Jay A. Berzofsky
Molecular Immunogenetics and Vaccine Research Section
Metabolism Branch
National Cancer Institute
Bethesda, MD
Telephone: +1 301 496 6874
Fax: +1 301 496 9956
Email: berzofsk@helix.nih.gov

(C) Nature Medicine press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2016 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.