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Amplifications of a region of chromosome 2p13 have been observed in various B-cell malignancies. After having ruled out several candidate genes, British, German and US researchers were able to identify the BCL11A gene and its 3 major RNA isoforms as the pathologic target for the amplification (Blood. 2001 Dec 1; 98(12):3413-3420). The researchers also reported that a previously identified translocation may contribute to deregulation of the BCL11A locus.
Contact :
P. W. Tucker
University of Texas at Austin, ESB 534, 100W 24th St,
Austin, TX 78705
E-mail: philtucker@mail.utexas.edu
or
Martin J. S. Dyer
Department of Haematology, University of Leicester
PO Box 65, Leicester, LE2 7LX, UK
E-mail: mjsd1@le.ac.uk.
Message posted by: Ulrike Sattler
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