Amplifications of a region of chromosome 2p13 have been observed in various B-cell malignancies. After having ruled out several candidate genes, British, German and US researchers were able to identify the BCL11A gene and its 3 major RNA isoforms as the pathologic target for the amplification (Blood. 2001 Dec 1; 98(12):3413-3420). The researchers also reported that a previously identified translocation may contribute to deregulation of the BCL11A locus.
P. W. Tucker
University of Texas at Austin, ESB 534, 100W 24th St,
Austin, TX 78705
Martin J. S. Dyer
Department of Haematology, University of Leicester
PO Box 65, Leicester, LE2 7LX, UK
Message posted by: Ulrike Sattler