home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Interferon-Alpha-Producing Cell Identified: Critical "Fast-Response" Component

 
  December, 3 2001 9:24
your information resource in human molecular genetics
 
     
How do our bodies know when a virus is lurking about? In the December issue of Nature Immunology, Trinchieri and colleagues at the Schering-Plough Research Institute in Dardilly, France, report the identity in mice of a specialized immune surveillance cell that specifically responds to the presence of viruses by rapidly releasing massive amounts of interferon-alpha, which induces an anti-viral state throughout the individual.

Consider our attention to the upcoming flu season as an example of the importance of generating anti-viral responses. Trinchieri shows that interferon-alpha-producing cells (IPCs), which were identified earlier in humans and now also shown here in mice, resemble immature dendritic cells. However, they must have some non-obvious specializations, as these cells do not respond to bacterial stimuli and differ in expression of surface proteins that may distinguish both their localization within tissues and, presumably, their function in the body. These IPCs are the major producers of interferon-alpha, which plays a crucial role in limiting early virus spread and activates cellular mechanisms that, as the name implies, interfere with viral replication. Finally identifying this cell in mice provides us with a system in which to test for the optimal means of inducing IPCs when needed.

Author contact:
Giorgio Trinchieri
Schering-Plough Research Institute
Dardilly, France
Tel: + 33 4 72 17 27 00
E-mail: Giorgio.Trinchieri@spcorp.com

Additional contact for comment on paper:
David F. Tough
The Edward Jenner Cancer Institute
Newbury, UK
Tel: +44 1635 577915
E-mail: david.tough@jenner.ac.uk

(C) Nature Immunology press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2016 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.