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Mismatch repair deficiency triggers gene amplification

 
  December, 3 2001 9:20
your information resource in human molecular genetics
 
     
Gene amplification is indicative of progressive genomic instability and thus a common feature of cancerous cells. Mismatch repair proteins like MLH1 and MSH6 are implicated in the removal of DNA replication errors. So far, a deficiency in mismatch repair has been associated with a predisposition to HNPCC, a form of colorectal cancer. The group of Paul Modrich has now shown that the rate of gene amplification is elevated 50- to 100-fold in human cell lines deficient in MLH1 or MSH6, as compared with mismatch-proficient control cells (Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13802-7). These results illustrate a new role for the mismatch repair proteins in the prevention of gene amplification whose failure may contribute to cancer progression.

Contact :
Paul Modrich
Department of Biochemistry, Box 3711
Duke University Medical Center, Durham, NC 27710
E-mail: modrich@biochem.duke.edu


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