home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Mismatch repair deficiency triggers gene amplification

  December, 3 2001 9:20
your information resource in human molecular genetics
Gene amplification is indicative of progressive genomic instability and thus a common feature of cancerous cells. Mismatch repair proteins like MLH1 and MSH6 are implicated in the removal of DNA replication errors. So far, a deficiency in mismatch repair has been associated with a predisposition to HNPCC, a form of colorectal cancer. The group of Paul Modrich has now shown that the rate of gene amplification is elevated 50- to 100-fold in human cell lines deficient in MLH1 or MSH6, as compared with mismatch-proficient control cells (Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13802-7). These results illustrate a new role for the mismatch repair proteins in the prevention of gene amplification whose failure may contribute to cancer progression.

Contact :
Paul Modrich
Department of Biochemistry, Box 3711
Duke University Medical Center, Durham, NC 27710
E-mail: modrich@biochem.duke.edu

Message posted by: Ulrike Sattler

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.