|
|
|
Gene amplification is indicative of progressive genomic instability and thus a common feature of cancerous cells. Mismatch repair proteins like MLH1 and MSH6 are implicated in the removal of DNA replication errors. So far, a deficiency in mismatch repair has been associated with a predisposition to HNPCC, a form of colorectal cancer. The group of Paul Modrich has now shown that the rate of gene amplification is elevated 50- to 100-fold in human cell lines deficient in MLH1 or MSH6, as compared with mismatch-proficient control cells (Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13802-7). These results illustrate a new role for the mismatch repair proteins in the prevention of gene amplification whose failure may contribute to cancer progression.
Contact :
Paul Modrich
Department of Biochemistry, Box 3711
Duke University Medical Center, Durham, NC 27710
E-mail: modrich@biochem.duke.edu
Message posted by: Ulrike Sattler
|
|
Variants Associated with Pediatric Allergic Disorder
Mutations in PHF6 Found in T-Cell Leukemia
Genetic Risk Variant for Urinary Bladder Cancer
Antibody Has Therapeutic Effect on Mice with ALS
Regulating P53 Activity in Cancer Cells
Anti-RNA Therapy Counters Breast Cancer Spread
Mitochondrial DNA Diversity
The Power of RNA Sequencing
‘Pro-Ageing' Therapy for Cancer?
Niche Genetics Influence Leukaemia
Molecular Biology: Clinical Promise for RNA Interference
Chemoprevention Cocktail for Colon Cancer
more news ...
|