Two routes to FAK activation and cancer cell migration
Changes in the distribution and activity of the focal adhesion kinase (FAK) help induce cancer cells to become invasive. Working with cultured pancreatic cancer cells, Sumitomo and coworkers have now identified a dual pathway by which the cell surface transmembrane proteinase neutral endopeptidase (NEP) regulates FAK phosphorylation and cell migration.
Journal of Clinical Investigation
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