home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Tumor Destruction Prevented By Natural IL-13

 
  December, 2 2000 3:26
your information resource in human molecular genetics
 
     
Certain tumors exhibit a growth-regression-recurrence pattern. Immune cells, called killer cells, mediate regression of the tumor but cannot completely eliminate the cancer. The mechanism by which such tumors escape surveillance by the killer cells is not known. In the December issue of Nature Immunology (Vol. 1, No. 6, 01 Dec 2000), scientists from the National Cancer Institute, Bethesda, USA, used a mouse tumor model, in which the tumor spontaneously regresses and then recurs, to study this phenomenon.

Scientists have implicated a protein called interleukin 13 (IL-13) in helping tumors to evade the killer cells. Rare cells, called natural killer T (NKT) cells, were found to be major producers of IL-13 in the body and it was discovered that depletion of IL-13 or NKT cells protects mice from tumor recurrence. The mechanism by which IL-13 reduces killer cell efficiency has yet to be determined. However, it is clear that therapies that can inhibit IL-13 production may be a useful tool in the fight against cancer.

A News & Views was written on this paper by Mark J. Smyth of the Peter MacCallum Cancer Institute, Australia.

Contact Information:

Jay Berzofsky
National Institutes of Health
National Cancer Institute
Building 10, Room 6B-12
Bethesda, MD 20892
Tel: +1 301-496-6874
Fax: +1 301-480-0681
berzofsk@helix.nih.gov

Mark Smyth
Peter MacCallum Cancer Institute
Cancer Immunology
Locked Bag 1
A'Beckett St
Victoria, 8006
AUSTRALIA
Tel: +61 3-9656-3728
Fax: +61 3-9656-1411
m.smyth@pmci.unimelb.edu.au

(C) Nature Immunology press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2016 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.