home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

A New Virulence Mechanism For MRSA

  November, 14 2007 19:32
your information resource in human molecular genetics
Strains of methicillin-resistant staphylococcus aureus (MRSA) that are acquired in the community may be more virulent than hospital-associated strains because they secrete small peptides that disable immune cells, as reported in Nature Medicine.

The majority of infections seen in the emergency room in the US are due to community-associated (CA) MRSA. Some strains of CA-MRSA can be especially virulent, causing sepsis and skin infections. Michael Otto and colleagues found that CA-MRSA strains produce much higher levels of a cluster of small peptides -- called phenol soluble modulins -- than strains of bacteria acquired from hospitals. The authors showed that mutant bacteria that couldn't make these peptides were much less virulent in mice.

The peptides seem to have several functions that allow the bacteria to cause severe disease: they contribute to activation of inflammation, and also kill neutrophils and red blood cells. As neutrophils are key immune cells involved in clearing bacterial infections, secretion of phenol soluble modulins seems to be one way that CA-MRSA evades elimination by the immune system

Author contact:

Michael Otto (NIAID, Hamilton, MT, USA)
E-mail: motto@niaid.nih.gov

Abstract available online.

(C) Nature Medicine press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.