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Lung Cancer Characterization

 
  November, 14 2007 18:46
your information resource in human molecular genetics
 
     
A huge overview of genetic alterations in lung cancer is presented online in Nature. The study takes a new approach to analysing copy number changes in lung adenocarcinoma, identifying a gene that has a significant role in many of these tumours.

Matthew Meyerson and colleagues analyse a large collection of tumours and identify 31 recurrent focal events, including 24 amplifications and 7 deletions occurring on both alleles. A new candidate oncogene, NKX2-1, is shown to be significant in a large number of lung cancers.

The results, when added to other such recent studies, illustrate the power of systematic copy-number analysis.

Author contact:

Matthew Meyerson (Dana-Farber Cancer Institute, Boston, MA, USA)
E-mail: matthew_meyerson@dfci.harvard.edu

(C) Nature press release.


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