A huge overview of genetic alterations in lung cancer is presented online in Nature. The study takes a new approach to analysing copy number changes in lung adenocarcinoma, identifying a gene that has a significant role in many of these tumours.
Matthew Meyerson and colleagues analyse a large collection of tumours and identify 31 recurrent focal events, including 24 amplifications and 7 deletions occurring on both alleles. A new candidate oncogene, NKX2-1, is shown to be significant in a large number of lung cancers.
The results, when added to other such recent studies, illustrate the power of systematic copy-number analysis.
Matthew Meyerson (Dana-Farber Cancer Institute, Boston, MA, USA)
(C) Nature press release.
Message posted by: Trevor M. D'Souza