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Lymphoma gene found

 
  November, 16 2001 4:05
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Lymphoma gene found

Scientists have discovered that a single defective copy of the gene, Dmp1, is sufficient to drive cancer development in a mouse model of B-cell lymphoma. Although one half of human cancers have mutations in the tumor suppressor gene, p53, half do not. Published in Genes & Development, this discovery represents a major breakthrough in the determination of the genetic factors that underlie tumor development in cells in which the more common tumor suppressor genes, like p53, are not mutated.

Contact:
Nora Poppito
poppito@cshl.org
Cold Spring Harbor Laboratory


Message posted by: Wouter Kalle

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