Lymphoma gene found

Scientists have discovered that a single defective copy of the gene, Dmp1, is sufficient to drive cancer development in a mouse model of B-cell lymphoma. Although one half of human cancers have mutations in the tumor suppressor gene, p53, half do not. Published in Genes & Development, this discovery represents a major breakthrough in the determination of the genetic factors that underlie tumor development in cells in which the more common tumor suppressor genes, like p53, are not mutated.

Contact:
Nora Poppito
poppito@cshl.org
Cold Spring Harbor Laboratory

Message posted by: Wouter Kalle