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Lymphoma gene found

  November, 16 2001 4:05
your information resource in human molecular genetics
Lymphoma gene found

Scientists have discovered that a single defective copy of the gene, Dmp1, is sufficient to drive cancer development in a mouse model of B-cell lymphoma. Although one half of human cancers have mutations in the tumor suppressor gene, p53, half do not. Published in Genes & Development, this discovery represents a major breakthrough in the determination of the genetic factors that underlie tumor development in cells in which the more common tumor suppressor genes, like p53, are not mutated.

Nora Poppito
Cold Spring Harbor Laboratory

Message posted by: Wouter Kalle

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