Foxo1 and the insulin resistance of cultured kidney cells

As a normal aspect of energy metabolism, cells in the kidney, much like those in the liver, respond to insulin by suppressing the metabolic pathways by which glucose is generated and released. In the healthy kidney, expression of the enzyme glucose 6-phosphatase (G6P), which controls a key step in glycogen breakdown, is suppressed by insulin. Curiously, this and other aspects of the transcriptional control by insulin are lacking in cultured kidney cells.

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John Ashkenas
scied@the-jci.org
416-946-7593
Journal of Clinical Investigation

Message posted by: Wouter Kalle