home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

New Fly Model Developed For Spinocerebellar Ataxia Type 1 (Sca1)

  November, 2 2000 1:41
your information resource in human molecular genetics

Juan Botas and colleagues at the Baylor College of Medicine, Houston, Texas, (Nature, Vol. 408, No. 6808, 02 Nov 2000) have developed a new fly model of the human neurodegenerative disorder Spinocerebellar ataxia type 1 (SCA1). They have engineered fruit flies to express either the normal human ataxin-1 protein, or a mutated form of the protein with expanded repeats of the amino acid glutamine, in the fly nervous system. The flies with the mutant protein have the same abnormalities as are seen in SCA1.

Botas and colleagues used this model to identify new proteins involved in the pathogenesis of SCA1. Mutations that affected the development of the disease were found in genes encoding proteins involved in the control of protein folding, in the clearance of misfolded proteins, cellular detoxification, the control of gene expression, and the control of the subcellular localization of proteins.


Juan Botas
tel +1 713 798 5937
fax +1 713 798 5386
e-mail jbotas@bcm.tmc.edu

(C) Nature press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.