Anticoagulant drugs, such as streptokinase and tissue plasminogen activator (tPA), are widely used to treat and prevent blood clots, but they carry a risk of causing serious hemorrhage. In the November issue of Nature Biotechnology, Bruce Sullenger and colleagues report that an unconventional drug, comprising the nucleic acid RNA, is efficacious in animals as an anticoagulant. What's more, it comes with its own antidote (an RNA complement that binds and neutralizes the drug), allowing better control of anticoagulant activity, which may be important in settings such as the surgical operating theatre where anticoagulants are often needed.
The drug and the antidote were shown to work in clinically predictive models of cardiovascular disease in both pigs and mice. In addition, the antidote prevented hemorrhage in the clipped tails of mice that had received the anticoagulant, demonstrating the efficacy of the antidote in a surgical trauma model.
Bruce Sullenger (Duke University Medical Center, Durham, NC, USA)
Tel: +1 919 684 6375, E-mail: firstname.lastname@example.org
Also available online.
(C) Nature Biotechnology press release.
Message posted by: Trevor M. D'Souza
Bookmark and Share this page (what is this?)
Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.
Use the links below to share this article on the social bookmarking site of your choice.
Read more about social bookmarking at Wikipedia - Social Bookmarking
Variants Associated with Pediatric Allergic Disorder
Mutations in PHF6 Found in T-Cell Leukemia
Genetic Risk Variant for Urinary Bladder Cancer
Antibody Has Therapeutic Effect on Mice with ALS
Regulating P53 Activity in Cancer Cells
Anti-RNA Therapy Counters Breast Cancer Spread
Mitochondrial DNA Diversity
The Power of RNA Sequencing
‘Pro-Ageing' Therapy for Cancer?
Niche Genetics Influence Leukaemia
Molecular Biology: Clinical Promise for RNA Interference
Chemoprevention Cocktail for Colon Cancer
more news ...