Misfolding the key to protein's ability to kill brain cells
Researchers may have discovered how prions can kill nerve cells in the brain and lead to some serious degenerative diseases. The key lies in how one particular protein misfolds within an organelle inside the cell, transforming itself into a new agent and then poisoning the neuron in which it was made. This may offer the best explanation to date of how these diseases are able to destroy individual nerve cells and ultimately kill patients.
National Institutes of Health, Howard Hughes Medical Institute
Ohio State University
Message posted by: Wouter Kalle