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Developmental control of tumor suppressor gene methylation

  October, 18 2001 4:46
your information resource in human molecular genetics
Developmental control of tumor suppressor gene methylation

Methylation at CpG dinucleotides, the best undersood epigenetic mechanism in mammals, allows cells to silence transcription of particular genes in a relatively stable manner. This process seems to be at work during tumorigenesis in the epigenetic silencing of certain growth inhibitory genes.

John Ashkenas
Journal of Clinical Investigation

Message posted by: Wouter Kalle

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