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Developmental control of tumor suppressor gene methylation

 
  October, 18 2001 4:46
your information resource in human molecular genetics
 
     
Developmental control of tumor suppressor gene methylation


Methylation at CpG dinucleotides, the best undersood epigenetic mechanism in mammals, allows cells to silence transcription of particular genes in a relatively stable manner. This process seems to be at work during tumorigenesis in the epigenetic silencing of certain growth inhibitory genes.

Contact:
John Ashkenas
scied@the-jci.org
416-946-7593
Journal of Clinical Investigation


Message posted by: Wouter Kalle

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