home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Studies On The Chemical Receptor P2X3 Offer Clues On How Animals Feel Pain

 
  October, 26 2000 2:22
your information resource in human molecular genetics
 
     
PAIN GAIN

This week, two groups (Nature, Vol. 407, No. 6807, 26 October 2000) describe experiments that mark a milestone in our understanding of how animals feel pain. Mice missing a chemical receptor molecule called ‘P2X3’ seem to feel less pain in certain situations. Furthermore, the results could help develop therapies against human conditions such as overactive bladder disorder.

Debra Cockayne of Roche Bioscience, Palo Alto, California and colleagues (pp. 1011-1015) find that genetic ‘knockout’ mice incapable of producing P2X3 lick painful paws less often. This is because the chemical ‘ATP’ that normally binds to the P2X3 receptor to cause pain can no longer do so. In addition, the mice urinate less frequently because full bladders also produce the chemical ‘ATP’ that binds the same receptor.

The second research team, led by John Wood of University College London, UK (pp. 1015-1017) also see reduced painful paw-licking in P2X3 knockout mice. But they find that skin inflammation pain is aggravated — a note of caution over possible pain treatments that target the receptor molecule. Curiously, the team also discovers the mice cannot sense mild skin warming.

Sean Cook and Edwin McCleskey of Oregon Health Sciences University, Portland, discuss this research in an accompanying News and Views article (pp. 951-952).

CONTACT:

Debra Cockayne
tel +1 650 354 2519
fax +1 650 855 1238
e-mail debra.cockayne@roche.com

John Wood
tel +44 207 380 7800
fax +44 207 679 3519
e-mail j.wood@ucl.ac.uk

Edwin McCleskey
tel +1 503 494 6933
fax +1 503 494 6972
e-mail mccleske@ohsu.edu

(C) Nature press release.



Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2016 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.