home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Persistent Infection Impairs The Immune System

 
  September, 23 2003 8:32
your information resource in human molecular genetics
 
     
Defective T cell responses are a common feature of patients with certain infectious diseases, autoimmune disorders and cancers that differ widely in their causes and symptoms. In the October issue of Nature Immunology scientists have now identified persistent infection as the major factor linking these diverse pathologies.

Michal Baniyash and colleagues from Hebrew University, Israel, hypothesized that persistent exposure to antigen could account for the impaired T cell responses observed in different diseases. Animals persistently exposed to bacteria had poor T cell responses - examination of the T cell receptor complex showed defective zeta chain expression on the cell surface. Importantly, chronic bacterial infection reduced the ability of the animal to fight influenza infection. The authors hypothesize that zeta chain down-regulation could be a physiological mechanism that helps prevent overblown immune responses. However, it can act as a double-edged sword by impairing the ability to respond adequately to chronic diseases.

Author contact:

Michal Baniyash
The Hebrew University of Jerusalem, Israel
Tel: +972 2 632 4653
E-mail: baniyash@cc.huji.ac.il

Additional contact for comment on paper:

Claudio Bordignon
Instituto Scientifico HS Raffaele, Milan, Italy
Tel: +39 02 2643 2351
E-mail: claudio.bordignon@hsr.it

Also available online.

(C) Nature Immunology press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2016 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.