A circadian clock within the brain ensures that we sleep at night and are awake during the day. But as anyone who has stayed up all night and fallen into a deep sleep the next morning knows, the timing of sleep also depends on the need for sleep. Now a paper in the October issue of Nature Neuroscience reports that sleep homeostatic processes, which cause the urge to sleep to depend on prior amounts of sleep or wakefulness, influence the circadian clock.
Johanna Meijer and colleagues monitored the vigilance state of rats by recording their brain (EEG) and muscle (EMG) signals. At the same time, the experimenters recorded neuronal activity within a brain region called the suprachiasmatic nucleus (SCN) to monitor the output of the circadian clock. Driven by cycles of gene transcription and translation, activity in the SCN normally oscillates with day and night cycles. They found a clear correlation between vigilance states and activity in the SCN. Furthermore, by using sleep deprivation experiments, they tested for a casual relationship. Indeed, during sleep deprivation, neuronal activity in the SCN failed to show expected changes in electrical activity for the time of day, demonstrating that activity in the SCN is determined not only by the molecular machinery of the circadian clock, but also by sleep need. A next step will be to determine how changes in need for sleep are communicated to the SCN at the molecular level.
University of Leiden, The Netherlands
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University of California at Los Angeles, Los Angeles, CA, USA.
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Article available online.
(C) Nature Neuroscience press release.
Message posted by: Trevor M. D'Souza
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