ADHD in a SNAP: The SNAP gene in attention deficit hyperactivity
Attention Deficit Hyperactivity Disorder (ADHD) is a neuropsychiatric condition characterized by hyperactive-impulsive behavior and persistent inattention. The coloboma mouse mutant has a hyperactive phenotype similar to that of ADHD. This model was shown to be the result of a deletion of the SNAP-25 gene. We analysed 93 Irish ADHD nuclear families and found increased preferential transmission of SNAP-25/DdeI variant to ADHD cases. This provides preliminary evidence for the involvement of SNAP-25 in predisposing to ADHD.
Message posted by: Wouter Kalle