Multiple sclerosis (MS) is associated with the genes, DRB1 and DRB5, but it is not known why these are MS risk factors. In Nature Immunology, scientists show that both DRB1 and DRB5 influence susceptibility to MS because they are structurally equivalent, which can potentially confuse the immune system during infection and trigger the immune system to attack the body.
Yvonne Jones and her team from Oxford University showed that a T cell clone taken from an MS patient could recognize both Epstein Barr Virus (EBV) and myelin, a component of the nervous system. EBV is presented to the T cells by DRB5 whereas myelin is presented by DRB1. Structural analysis of the DRB5-EBV complex revealed a remarkable degree of structural similarity to the DRB1-myelin complex in the region important for T cell recognition. Therefore, a virus infection such as EBV could trigger MS in genetically susceptible individuals because the T cells induced by the virus also cross-react with tissues from the nervous system.
E. Yvonne Jones
Department of Structural Biology
Tel: +44 1865 287559
(C) Nature Immunology press release.
Message posted by: Trevor M. D'Souza
Bookmark and Share this page (what is this?)
Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.
Use the links below to share this article on the social bookmarking site of your choice.
Read more about social bookmarking at Wikipedia - Social Bookmarking
Variants Associated with Pediatric Allergic Disorder
Mutations in PHF6 Found in T-Cell Leukemia
Genetic Risk Variant for Urinary Bladder Cancer
Antibody Has Therapeutic Effect on Mice with ALS
Regulating P53 Activity in Cancer Cells
Anti-RNA Therapy Counters Breast Cancer Spread
Mitochondrial DNA Diversity
The Power of RNA Sequencing
‘Pro-Ageing' Therapy for Cancer?
Niche Genetics Influence Leukaemia
Molecular Biology: Clinical Promise for RNA Interference
Chemoprevention Cocktail for Colon Cancer
more news ...