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Diabetic Drug Could Treat Common Liver Problem

 
  September, 11 2000 8:05
your information resource in human molecular genetics
 
     
As many as one quarter of adults in industrialized countries have excessive fat accumulation in the liver (fatty liver), a common cause of chronic liver disease which is frequently associated with obesity and diabetes.

Based on the understanding that fatty liver is associated with low levels of insulin and insulin-resistance, Anna Mae Diehl and coleagues at Johns Hopkins University tested the ability of the oral diabetes drug, metformin - which sensitizes the body to the effects of insulin - to improve the condition Nature Medicine (Vol 6, No. 9, September 2000).

The team found that metformin improved fatty liver disease in mice with a mutation in the obese (ob) gene, which develop obesity, diabetes and fatty liver. They propose that metformin achieves this by inhibiting liver production of tumor necrosis factor (TNF)a which promotes lipid accumulation.

Dr. Anna Mae Diehl
The Johns Hopkins University
GI Divivsion, 912 Ross Bldg.
720 Rutland Street
Baltimore, MD 21205
Phone #: 1 410 955 7316
Fax #: 410 955 9677
Email Address: amdiehl@welch.jhu.edu

(C) Nature Medicine press release.


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