home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Research Reveals Link Between Allergic Asthma and an Immune Molecule, C5

 
  September, 1 2000 2:55
your information resource in human molecular genetics
 
     
Genetic clue to causes of allergic asthma

Nature Immunology, pages 221-226, News and Views pages 190-191.

The worldwide prevalence and severity of allergic asthma has increased dramatically in recent decades. Therapeutic advances are not keeping pace, and consequently morbidity and mortality continue to rise. It is thought that allergic asthma arises as a result of inappropriate immunological responses to common environmental substances in genetically susceptible individuals.

In the September issue of Nature Immunology [Vol. 1, No. 3], using microarray state-of-the-art technology, researchers from the Johns Hopkins University, Baltimore, MD, have tracked down a link between allergic asthma and an immune molecule, C5.

In mice, interleukin 12 (IL-12) is able to prevent or reverse allergic asthma, and one of the roles of C5 is to activate certain immune cells to produce IL-12, thus providing a link between C5 and asthma. The research group demonstrated in mice that blocking of the C5 receptor resulted in no IL-12 production and the consequent induction of allergic asthma. This gives us useful targets in the fight against allergic asthma.

A News & Views on this paper was written by Dr. Peter Henson of the National Jewish Medical and Research Center.

Contact Information:

Article:
Marsha Wills-Karp Johns
Hopkins University School of Hygiene and Public Health
Department of Environmental Health Sciences
615 North Wolfe Street
Baltimore, MD 21205
Tel: 410-955-3612
Fax: 410-955-0299
E-mail: ckarp@jhmi.edu

N&V:
Peter Henson
National Jewish Medical and Research Center
Department of Pediatrics
1400 Jackson St., Rm. D508
Denver, CO 80206-2761
Tel: 303 398-1380
Fax: 303 398-1381
E-mail: hensonp@njc.org

(C) Nature Immunology press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2016 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.