home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

To Mend A Broken Heart

 
  August, 7 2007 22:04
your information resource in human molecular genetics
 
     
A study in the August 2007 issue of Nature Medicine reports that stem cells help the heart to regenerate after injury, but not during normal ageing.

The question of whether stem cells exist in the heart that can generate muscle cells during ageing or after injury has been highly controversial. To resolve this controversy, Richard Lee and colleagues have taken a novel genetic approach that overcomes many of the technological limitations of previous work. These authors used a genetically modified mouse in which mature heart cells (but not cardiac stem cells) are labelled with a fluorescent protein early in the life of the animal. The authors reasoned that, if stem cells replenish the heart, the percentage of labelled heart cells would decrease over time. But if they don't, the percentage would remain unchanged. So, they looked for the fluorescent label as their mice got older or in response to injury.

The researchers found that, during normal ageing, the percentage of labelled heart cells did not change. By contrast, after heart attack and another form of heart injury, the percentage of labelled heart cells decreased. So, cardiac stem cells replenish heart cells in response to injury, but not as the heart ages. These findings should help sway those who have been sceptical of the existence of heart stem cells. The physiological basis for the intriguing difference between stem cell function in injured and ageing hearts remains to be explored.

Author contact:

Richard Lee (Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA)
E-mail: rlee@partners.org

Abstract available online.

(C) Nature Medicine press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.