home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Defining the Active Site of Bax

 
  August, 6 2007 4:46
your information resource in human molecular genetics
 
     
In the August 1st issue of of G&D, scientists from the University of Nebraska Medical Center, led by Dr. Xu Luo, have identified the long-sought-after homo-oligomerization domain of Bax. The researchers demonstrate that the homo-oligomerization domain is, in fact, responsible for Bax's apoptotic activity. Structural analysis revealed that a three-helix unit ­ consisting of helix 2 from the BH3 domain, and helices 4 and 5 from the BH1 domain ­ together form the homo-oligomerization domain.

Dr. Luo and colleagues went on to show that this is the minimal domain required for the permeabilization of the mitochondrial membrane and the corresponding induction of apoptosis. "How activated Bax (or Bak) causes mitochondrial damage remains one of the most fascinating and important questions in apoptosis research. Establishing the causal relationship between homo-oligomerization and apoptotic activity of Bax and the identification of the Bax homo-oligomerization domain represent one step forward towards answering that question," explains Dr. Luo.


Source: Genes and Development Press Release


Message posted by: Robin Kimmel

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.