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Scientists Identify New Genetic Risk Factors for Multiple Sclerosis

 
  August, 1 2007 14:38
your information resource in human molecular genetics
 
     
A pair of large-scale genetic studies supported by the National Institutes of Health has revealed two genes that influence the risk of getting multiple sclerosis (MS) — data sought since the discovery of the only other known MS susceptibility gene decades ago. The findings could shed new light on what causes MS — a puzzling mix of genes, environment and immunity — and on potential treatments for at least 350,000 Americans who have the disease.

"These studies describe the first genes conclusively linked to MS in more than 20 years," said Ursula Utz, Ph.D., a program director at the National Institute of Neurological Disorders and Stroke (NINDS), a part of NIH. "This breakthrough was made possible through persistence, an elegant search strategy, and genomic data and techniques that were not available until recently."

Both studies involved scanning DNA samples from more than 20,000 MS patients and unaffected individuals in the U.S. and Europe, and looking for single nucleotide polymorphisms (SNPs), which are single-letter variations in a gene's DNA code. Published simultaneously today in the New England Journal of Medicine and Nature Genetics, the studies demonstrate an association between MS and SNPs in two genes that encode interleukin receptors, proteins that serve as antennae on the surface of immune cells.

CONTACT:
Daniel Stimson
301-496-5751


Message posted by: Rashmi Nemade

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