home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Cystic Fibrosis: Explaining Persistent Lung Infections

  August, 31 2006 6:19
your information resource in human molecular genetics
In the September 2006 issue of Nature Cell Biology, Deborah Nelson and colleagues show that CFTR - cystic fibrosis transmembrane regulator, the protein that malfunctions in cystic fibrosis - can control the acidity of digestive compartments in the cell, causing a defect in their ability to kill bacteria.

Bacterial infections in the lungs of cystic fibrosis patients can cause chronic inflammation, which in turn induces tissue damage and worsens the symptoms of the disease. One way that cells clear bacterial infection is through phagocytosis - where specialized cells, called macrophages, ingest the bacteria and destroy them by digestion in acidic compartments. The authors found that CFTR, a chloride ion channel, is present in particular macrophage cells that function specifically in the lung. Using macrophages obtained from mice that are genetically engineered to no longer express the CFTR protein, or by specifically inhibiting CFTR, the authors show that there is a defect in acidification of the digestive compartment in the cell. As a result, an alkaline environment persists, permitting bacterial growth and division.

Macrophages are a key player in the body's defence mechanism. Compromising their function, as shown by Nelson and colleagues, may begin to explain the persistent infections observed in cystic fibrosis patients

Author contact:

Deborah J Nelson (University of Chicago, IL, USA)
E-mail: nelson@uchicago.edu

Abstract available online.

(C) Nature Cell Biology press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.