The ADAM33 gene has recently been identified as being a potentially important asthma candidate gene, and polymorphisms in this gene have been shown to be associated with asthma and bronchial hyperresponsiveness in Caucasian individuals from several populations.
Professor Thompson and his group, in their analysis of ADAM33 haplotypes (European Journal of Human Genetics, Vol. 14, pp. 1027-1036), suggest a likely role for ADAM33 in the asthma phenotype.
Professor P. J. Thompson, Asthma and Allergy Research Institute, Ground Floor E Block, Sir Charles Gairdner Hospital, Nedlands, WA, 6009, Australia.
Abstract available online.
(C) European Journal of Human Genetics.
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