Restless legs syndrome (RLS) is a common neurological condition with three loci (12q, 14q, and 9p) described so far, although none of these genes has yet been identified. In a paper published in the American Journal of Human Genetics, the authors (Pichler et al.) report a genome-wide linkage scan of patients with RLS (n = 37) assessed in a population isolate (n = 530) of South Tyrol (Italy). Their findings reemphasize the genetic heterogeneity of the disorder and strongly support the identification of a novel locus for RLS on chromosome 2q.
Peter P. Pramstaller, Department of Neurology, General Regional Hospital, Bolzano, Italy.
Table of Contents of Volume 79 (No. 3) with links to Abstracts: TOC.
(C) American Journal of Human Genetics.
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