home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Active Sites Of A Hepatitis C Virus Enzyme Revealed

  August, 2 2006 8:59
your information resource in human molecular genetics
The crystal structure of one of the hepatitis C viral proteins could offer new opportunities for antiviral drug design, report Charles Rice and colleagues in a paper published online by Nature. The disease affects an estimated 170 million people worldwide, often leading to cirrhosis and liver cancer.

The viral genome encodes a single polyprotein, which cleaves into proteins including the NS2-3 protease. The crystal structure of the protease catalytic domain reveals a novel structure: it is actually a dimer (resembling a 'butterfly') composed of two identical proteins that each contributes amino acids to two equivalent active sites. The concentration and dimerization of NS2-3 may be a limiting factor in the viral life cycle because the protease is essential for viral replication. Details of the structure may help in the search for small-molecule inhibitors directed against the active site.


Charles Rice (The Rockefeller University, New York, NY, USA)
E-mail: ricec@rockefeller.edu

(C) Nature press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.